So this is neat. Potentially life changing for some type 2 diabetics, but that depends because some t2 diabetics are not failing to make enough insulin, they’re just no longer sensitive to it at a level that makes it functional for them. I suppose it’s possible that this therapy could cause them to grow enough islet β cells to overcome their lack of sensitivity, but (and I’m a type 1, not a type 2, so maybe my info is incorrect here) that lack of sensitivity can grow with further exposure to insulin making this a stop-gap at best for those cases absent other therapies.

…and with all of that said, being able to regrow islet β cells has never really been the problem for type 1 diabetes. You can regrow all the islet β cells you’d like and it’s not going to cure the underlying immune disease that has caused your immune system to kill off all of your islet β cells to begin with. Unless you can figure out why t1 diabetes causes one’s own immune system to go psycho killer on their islet β cells, you’ve done nothing to “cure” diabetes. Without being able to suppress that impulse for your immune system to murder your own cells, any ability to replace the islet β cells is going to be temporary at best, and probably a waste on the whole.

My brother in law is a “cured” type 1 diabetic, by virtue of his having had a kidney replacement and being on immune suppressing drugs for that. Since they were already replacing the kidney and he was going to have to take immune system suppression medications for that, they also just replaced his pancreas at the same time and the suppression of his immune system has allowed the new pancreas to thrive and continue to make insulin. Easy-peasy. The only trade-off is that he is super immunocompromised and can be killed by common colds, so not a great strategy in general.

The Nissan Connect stuff doesn’t work anymore for any of the 2016 Leafs, they used a form of cell service that is no longer in operation.

I swapped a nice Kenwood head unit into my Leaf for a couple hundred dollars. It maintains the backup camera, steering wheel controls, and the built in USB port while offering a larger screen and touch screen controls for Android Auto or Apple Car Play if you want them. It’s awesome and I highly recommend it for anyone who wants a short range commuter car.

I assume this is a Stargate thing and that there aren’t actually that many Skeptical Guide podcasts out there.

I haven’t got any dog in the Stargate fight, I’ve seen the original movie (good) and watched the Richard Dean Anderson TV series (better than the movie) for a while before it just fell off my radar? I’ll take your word for it that Stargate Universe is the lesser of the Stargate properties.

SGU in my comment obviously is referring to the Skeptics Guide to the Universe aka, the linked podcast.

I’ve never listened to Rogan*, but I think https://www.theskepticsguide.org/podcasts does an excellent job of talking about current news and science items in an easily digestible format that mostly avoids bullshit while probably filling the same gee-whiz niche that people expect from Rogan? It’s a panel, so not a single muscular male host, but I think if your sibling is pursuing Rogan because they think it’s helping expose them to new interesting ideas, SGU is a vastly superior route to that end.

*I actually think my only Rogan exposure has been the SGU talking about how he more or less just believes the last thing anyone told him, whatever that might be, which seems… less good?

https://www.patreon.com/Orioto

Might just be a me thing, but this guy puts out a new wallpaper almost every week and they’re all amazing. The higher tiers allow you to participate in choosing the next wallpaper, but they’re mostly for 1080p, 1440p, and 2160p. Buying in once gets you the whole lot of everything he’s done until now.

It’s a pretty great game. Really good music and one of those gameplay loops that is easy to pick up and difficult to master. If you like Tetris and the like, Lumines is worth your attention.

Lumines

My suggestion would be to reframe your thesis. Rather than consuming content, change your perspective to one where you are appreciating art.

The world is vast and full of amazing things, you don’t need to feel like you’re wasting time when you dedicate that time to appreciating art that you love. There are books, games, movies, short form video essays, podcasts, and all sorts of things that are real expressions of the human experience from different angles, which is what art is, and there’s nothing wrong with appreciating that art, learning something from it, and growing your understanding.

Unless you’re harming yourself or others by enjoying the art you enjoy, just keep on doing it.

That said, if you really want something else, gaming is (IMO) a great way to spend some time, tabletop or video. Learning a programming language is another one and can lead to very fulfilling paths where you can make things that you enjoy and easily share them with others.

I’ll be honest, I could sometimes find a helpful answer there, but for about the last 2 years it has taken 3 reloads of a page at least before it actually loads any content, otherwise it just sits there at a plain white page showing their logo and I usually give up rather than try to get lucky with a page actually loading.

How the fuck this headset weighs over 600 grams?

Because plastic isn’t a premium material. Apple users expect fancy alloys with glass everywhere, Apple can’t very well show up with a plastic headset and ask $3500 for it, they need all that extra weight to convince people that they’re getting a premium VR AR SPACIAL COMPUTING device that is unlike anything ever done before. It’s all part of the grift.

I’m a reformed VR enthusiast and I have got to say that it’s all a hell of a gimmick, but it’s just a really neat gimmick. Without any hard-light tech or something to make stuff that you can actually interact with it’s all just Wii-mote waggle style nonsense that abstracts things that should be button presses into complex motions constrained by physical reality that our computers/keyboards/mice/controllers allow us to escape.

Banning Social Media FOR KIDS. Is just a quick means to spy on what ADULTS are getting up to on the Internet. Right now if you don’t want to ID yourself to go see cat pics/videos on Instagram/TikTok, you can just sign up for an account and go searching for cat pics/videos. With this bill, if you want to go find cat pics/videos on Instagram/TikTok in the state of Florida, you’ll have to submit a government ID to verify that you’re not a kid, and I’d believe for about as long as I can breathe water that the linking of my real identity/government ID with a social media account will have no negative real world outcomes.

Cybersecurity is something that almost nobody takes seriously. I used to say that nobody takes it seriously until they’re hurt by their poor cyber hygiene, but these days the insurance policies pay the same either way so companies/people still do the bare minimum and call it a day.

I’d much rather pay a VPN provider to be out of that jurisdiction than ever give anyone anything that concretely ties my online persona to my actual identity and it’s just incredible that lawmakers so fundamentally misunderstand how this all works that they don’t know it’s that easy.

If Mr. Donaldson really wanted to know how much X was gonna give it to him he should have made a video about how Elon is a tiny man-child with an inferiority complex grown out of his inability to satisfy any woman and how Teslas are cheap made in China garbage piles that are handily bested by any other EV on the market in any metric. Only then, I MIGHT believe any revenue numbers he got from such a video, but I think what this article shows is happening is exactly how I’d expect things to go for any other video.

Elon is clearly gonna pull a Facebook and juice the numbers to lure people away from other platforms as long as he can in hopes of growing into something bigger than YouTube. I’d believe Elon’s numbers as much as I believe he owns a lovely bridge on Kepler-442b that he wants to sell me at an amazing loss.

Yeah, this is the real rub here. Without the co-op it’s not really anything special, there are even games out there doing Action RPG better these days so I can’t imagine why you’d choose to not embrace the couch/online co-op crowd that’d put this back at the head of the pack.

Yeah, I own Collection of Mana and Trials of Mana and played it both ways. Trials in particular has got me very excited for Visions, but I really hope that they’re doing multiplayer and ideally 3 player to throw back to the greatest aspect of Secret.

So much talk about “what makes a Mana game” in there, and yet for me the one thing that made Secret of Mana a game that I cared about was the 3 player co-op that absolutely ruled. Still no indication that this game even has 2 player action. I was super disappointed when I could finally play a fan translation of Seiken Densetsu 3 on PC back in the day and it was only 2 player, and lately I’ve been increasingly disappointed as everything since has been a single player affair.

Call me crazy, but the series hasn’t been great (it’s still been good, just shy of great) since the SNES outings and I am really wish they’d get the game back to the multiplayer that made it great.

I’m just going to copy/paste my comments from the last article 2 days ago that was saying this same thing:

This is the second third article in the last month I’ve found here on the Fediverse pronouncing the death of self checkout and honestly I just don’t see it. Most of the stores around me have only just recently expanded their self-checkout areas and I vastly prefer using it unless I’ve got more than 25 items.

I’d honestly probably stop going to a store that decided to not allow me to check out on my own. Small talk and having to make a minimum wage worker suffer through it is just not something I want when I’m running to the store for a gallon of milk. I vastly prefer being able to throw in some earbuds, get my shopping, check out, and get out to having to interact with anyone while I’m just trying get my shit.

You get your ISPs email address, and you could have your Google address, what else?

I host my own email. I have literally billions of email addresses available if I want them and getting billions more only costs however much I can get a new domain registration for, which isn’t often more than $10. I already own a dozen domains or more and I can have any username I want at any of those domains for any email at no additional cost.

Now I’m not some dickhead harassing people online or spamming discord servers, but I will admit that Wendy’s once had a deal where you could get a free frosty for creating a new account and I had free frosty coupons for weeks before they realized that email only verification for unique users was a losing proposition and they switched to requiring that new accounts attach a phone number.

Email verification only works if you’ve got nothing to lose. As soon as there’s anything on the line, you’d better look for something more concrete like a phone number, a credit card, or a government ID. Personally I’m more comfortable with Discord having one of those pieces of info before the other two, but that’s just me, you do you.

This is the second article in the last month I’ve found here on the Fediverse pronouncing the death of self checkout and honestly I just don’t see it. Most of the stores around me have only just recently expanded their self-checkout areas and I vastly prefer using it unless I’ve got more than 25 items.

I’d honestly probably stop going to a store that decided to not allow me to check out on my own. Small talk and having to make a minimum wage worker suffer through it is just not something I want when I’m running to the store for a gallon of milk. I vastly prefer being able to throw in some earbuds, get my shopping, check out, and get out to having to interact with anyone while I’m just trying get my shit.

If he weren’t a billionaire, he’d be sectioned/committed.

I mean, I think everyone has “that uncle” who they have to put up with for the holidays, and those guys are all walking around existing in non-sectioned/committed society. He’d just be another crank who is drinking the Kool-Aid instead of this rich fuck who everyone listens to despite their being whack-a-doo.

I genuinely hope that you’re kidding. If you’re not. No. Just no.