I work in Addiction Medicine and xylazine is not a new problem; the media is just now picking up on it. Certain states are not supportive of harm reduction (access to naloxone, syringe service programs, etc) which only makes xylazine in the drug supply worse.

Xylazine is not approved for use in humans. It is used as a sedative in veterinary medicine, which is why it’s referred to as “tranq” on the street. The closest drug we have in humans is clonidine. We are not sure how xylazine works in humans. Xylazine was previously studied in humans to treat hypertension; however, it was not approved by the FDA due to causing severe hypotension and bradycardia. It’s still extremely important to administer naloxone to suspected opioid ODs even if xylazine use is suspected even though naloxone has no affect on xylazine.

Xylazine is also cytotoxic and causes necrotic wounds and ulcerations in people who inject drugs.

I use a paid plexshare and it rules. Cost aside, it’s so convenient to have everything on one place, especially for kids shows.

Reddit proverbially taking their ball and going home lmao

Agreed. I have an account on lemmy.world, but I enjoy the community and interaction with the posts on beehaw. One user made a post saying that the defederation hurt Beehaw more than the other instances, but Beehaw has a lot of strong, active communities that the other instances don’t have.

Glad Twitch has a competitor, but I’ve never heard of Kick. Expecting this to go as well as Mixer

I agree. I started off creating an account on lemmy.world because I had no idea what I was doing in the fediverse (still don’t lmao). All this drama/defederation between lemmy.world and beehaw.org was annoying because I liked the posts from beehaw.org. Decided to give kbin a shot, which seems to be working well? The UX for lemmy and kbin are honestly gross and is taking a while to get used to.