VirusTotal doesn’t indicate keepassxc.exe 2.7.7 contacts this address. I’d be careful. Check the binaries’ signatures. Try a full install to see if that behaves differently.
keppassxc.exe: https://www.virustotal.com/gui/file/fea4df5024f83155f6742a3372a801fc6cc97ed82627b36fce6f0caed54506cf/relations
KeePassXC-2.7.7-Win64.msi: https://www.virustotal.com/gui/file/9c3dab957db0f769c4e67bfdf4f0134a65ecfa65c5569718a36aa88e649158cd
Well, apparently, this is an A record for api.github.com. This name resolves to a different IP around the globe. See https://www.whatsmydns.net/#A/api.github.com
The IP is detected as “clean” on VirusTotal: https://www.virustotal.com/gui/ip-address/140.82.121.5/detection , although apparently (probably not surprising as it is github) is also a favorite address for everything including malware.
Maybe you can ask in the keepassxc discussion forum on github.